This aging population is associated with a decline in physical and cognitive performance, including an increased incidence of cognitive impairment. Globally, approximately 50 million people currently live with dementia, and this number is projected to reach 152.8 million by 2050. In Indonesia, dementia cases are expected to exceed 4.2 million. Extensive research has shown that nonpharmacological interventions provide costeffective, convenient, and safe benefits for older adults with cognitive impairments.Among these, dietary therapy has been clinically validated as an effective treatment approach. Several studies have highlighted the role of probiotics in supporting cognitive function. This was an experimental study involving 48 subjects divided into 33 subjects as the intervention group and 15 as the control group and the study consisted of two phases: the preparation of the bacterial isolate (at a concentration of 10⁸ CFU/mL ) and the mixing of the beverage, followed by the provision of the intervention. Cognitive function assessments, focusing on memory (Word List Memory Immediate Recall) and language (verbal fluency and Boston Naming Test) domains using tools from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), were performed on the subjects before and after the intervention. Furthermore, mild cognitive impairments were identified using the MoCA-INA questionnaire an adaptation of the original version designed to accommodate cultural differences in Indonesia. The interventions provided to the two subject groups were intervention with Lp. plantarum TI isolates and without isolate for the control subjects. The study found that the intervention group showed significant improvements in the Boston Naming Test and MOCA total score, with mean scores increasing from pre- to post-intervention. The conclusion of the study that administration of probiotics derived from Lactiplantibacillus plantarum T1 at a concentration of 10⁸ CFU/mL for a 14-week intervention resulted in significant improvements in language abilities, global cognitive performance.  

Yvonne Suzy Handajani has completed her Doctor of Public Health from Indonesia University, Indonesia. She is the head of Health Research Centre of Atma Jaya Catholic University of Indonesia and also as Lecturer in Public Health and Nutrition Department of School of Medicine and Health Science. She has conducted a lot of research in collaboration with researchers at various research centres in Indonesia and abroad and also many manuscripts have been published on reputed journals.