Marina Bogomolova
The Mother and Child Clinic, Russian FederationPresentation Title:
How to increase the chance of pregnancy in women over 40 years of age
Abstract
The effectiveness of infertility treatment in older women of reproductive age remains low. In women over 40 the clinical incidence of spontaneous abortions is approaching 25%, 50% of diagnosed pregnancies in patients aged 45 years end in abortion. The main cause of pregnancy failure is aneuploidy.
In our work, we compared the score assigned by the EmbryoScope+ incubator and the result of PGT-A preimplantation genetic testing.
The study included the embryos of 106 women aged 24 to 46 years who applied to the Mother and Child Reproduction Clinic for infertility treatment using ART.
Our work revealed positive dynamics of embryo evaluation using artificial intelligence of the EmbryoScope+ incubator. In both groups of patients, the frequency of euploid embryos was higher at EmbryoScope scores of 8 and higher than at scores of 7-4, indicating that transferring embryos with high EmbryoScope scores increases the chances of selecting an euploid embryo without PGT-A testing.
In the patients of the older age group in the cohort of the best quality embryos (9-8 points), the incidence of embryo aneuploidy was 50%, which indicates the expediency of carrying out a genetic analysis of embryos in this group of patients.
Choosing the best embryo for transfer using the artificial intelligence of the EmbryoScope+ incubator significantly reduces infertility treatment time.
Biography
Marina Bogomolova was graduated from St. Petersburg State University Faculty of Biology with a degree in cytology. She is the head of the embryological laboratory at the Mother and Child Clinic in St. Petersburg. Member of the ESHRE, Senior Clinical Embryologist of the ESHRE
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