Ramakanth Pata
Centra Care Health System, USATitle: Analgesio-Sedation and delirium mitigation strategies in ARDS and septic shock, evidence based approach
Abstract
Delirium is often underdiagnosed in the ICU, with a reported prevalence of 20–80%,
especially in severely ill patients such as those with septic shock and acute respiratory
distress syndrome (ARDS). Delirium is often associated with poor outcomes, including
length of stay, quality of life, and mortality. Nursing plays a tremendous role in the
prevention and management of delirium. There has been increasing evidence suggesting
that, in addition to many organic causes, the choice and dose of sedative-analgesics may
influence the incidence of delirium. The presentation will focus on identifying risk
factors, assessment of delirium by CAM-ICU and the Intensive Care Delirium Checklist
(ICDSC), comparison between the two techniques, and evidence-based delirium
mitigation strategies influenced by the choice and dose of analgesics and sedatives,
including propofol, ketamine, and dexmedetomidine infusion (target-based sedation)
from the SEDCOM, MENDS, and KISS trials. Management often involves identifying
the triggers (with mnemonics such as DR.DRE: diseases, drug removal, and
environment). Once the life-threatening triggers are ruled out, non-pharmacological
measures such as reorientation, providing visual and hearing aids, improving sleep and
hygiene, and removing delirogenic drugs (such as benzodiazepines), including the
removal of catheters, restraints, and the potential use of antipsychotics, are frequently
employed. The use of the ABCDEF bundle (assess, prevent, and manage pain; both
spontaneous awakening and breathing trials; choice of appropriate sedation; delirium
monitoring and management; early mobility and exercise; family engagement and
empowerment) has been shown to decrease the incidence of delirium and improve
patient outcome.
Biography
Ramakanth Pata , MD graduated from the University of Cincinnati Medical Center in
2022. He is board certified in Internal medicine, Pulmonary and Critical Care medicine,
and anesthesiology. He is currently the principal investigator of many clinical trials at
CentraCare health System, focusing on improving outcomes in septic shock and ARDS.
He is the author of three books titled: 1. Emerging Principles of Intensive Care; 2.
Trauma Intensive Care: An Enchiridion; and 3. Hepatic Replacement Techniques: Cliche
or Ad-Rem Appurtenances. He published many articles, including the KISS study with
the focus on using ketamine in severe ARDS patients. He is also editor of four journals,
including the European Journal of Clinical Research, the World Journal of Respiratory
Medicine, Cureus (part of Springer Nature), and the Journal of Cardiology