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Ramakanth Pata

Centra Care Health System, USA

Title: Analgesio-Sedation and delirium mitigation strategies in ARDS and septic shock, evidence based approach

Abstract

Delirium is often underdiagnosed in the ICU, with a reported prevalence of 20–80%, especially in severely ill patients such as those with septic shock and acute respiratory distress syndrome (ARDS). Delirium is often associated with poor outcomes, including length of stay, quality of life, and mortality. Nursing plays a tremendous role in the prevention and management of delirium. There has been increasing evidence suggesting that, in addition to many organic causes, the choice and dose of sedative-analgesics may influence the incidence of delirium. The presentation will focus on identifying risk factors, assessment of delirium by CAM-ICU and the Intensive Care Delirium Checklist (ICDSC), comparison between the two techniques, and evidence-based delirium mitigation strategies influenced by the choice and dose of analgesics and sedatives, including propofol, ketamine, and dexmedetomidine infusion (target-based sedation) from the SEDCOM, MENDS, and KISS trials. Management often involves identifying the triggers (with mnemonics such as DR.DRE: diseases, drug removal, and environment). Once the life-threatening triggers are ruled out, non-pharmacological measures such as reorientation, providing visual and hearing aids, improving sleep and hygiene, and removing delirogenic drugs (such as benzodiazepines), including the removal of catheters, restraints, and the potential use of antipsychotics, are frequently employed. The use of the ABCDEF bundle (assess, prevent, and manage pain; both spontaneous awakening and breathing trials; choice of appropriate sedation; delirium monitoring and management; early mobility and exercise; family engagement and empowerment) has been shown to decrease the incidence of delirium and improve patient outcome.

Biography

Ramakanth Pata , MD graduated from the University of Cincinnati Medical Center in 2022. He is board certified in Internal medicine, Pulmonary and Critical Care medicine, and anesthesiology. He is currently the principal investigator of many clinical trials at CentraCare health System, focusing on improving outcomes in septic shock and ARDS. He is the author of three books titled: 1. Emerging Principles of Intensive Care; 2. Trauma Intensive Care: An Enchiridion; and 3. Hepatic Replacement Techniques: Cliche or Ad-Rem Appurtenances. He published many articles, including the KISS study with the focus on using ketamine in severe ARDS patients. He is also editor of four journals, including the European Journal of Clinical Research, the World Journal of Respiratory Medicine, Cureus (part of Springer Nature), and the Journal of Cardiology