One of the most common illnesses, periodontitis is a major public health problem because of its increasing prevalence and serious socioeconomic consequence. Traditional approaches to periodontal care often rely on reactive measures, addressing symptoms rather than underlying causes. The paradigm of predictive, preventive, personalized, and participatory (p4) precision periodontal care is modelled by medicine, leading to a big cultural effort in changing the actual “reactive” therapeutic point of view, belonging to the last century, into a futuristic “predictive” one. The futuristic “5Ps” (Predictive, Preventive, Personalised and Participatory Periodontology) focuses on the early integrated diagnosis (genetic, microbiology, biomarkers host- derived detection) and on the active role of the patient in which networked patients will shift from being mere passengers to responsible drivers of their health. This talk will address how these Ps will change the future of oral health care leading to a more personalised therapy. With equal patient and practitioner participation in comprehensive health care, P4 medicine adopts a new paradigm of integrative and holistic approaches to patient management.